Wednesday, September 23, 2009

Homocysteine, Genetics & Vitamins

Homocysteine (HCY) is a tool used by your body to modify protein. Specifically, homocysteine carves up the amino acid methionine into smaller amino acids. Each of these amino acids has important functions. The "leftovers" from this construction project are not thrown away. Instead, your body recombines the debris back into methionine again.

Methionine is the protein that serves as the foundation for all other proteins. It's like concrete:

You can build a small cottage or a large skyscraper on the same concrete foundation. You can build brain cells, heart cells, bone cells, and healthy cells for your entire body on the protein methionine. Homocysteine is responsible for crafting that foundation. While homocysteine is an excellent tool for your body, too much of it can be fatal.

It's in the genes

There is a common gene defect among people in North America. It is called an MTHFR defect. It allows homocysteine to escape into the bloodstream and literally shred your arteries, causing a stroke; tangle your brain cells causing Alzheimer's disease; shatter your bones causing osteoporosis; and inflame your heart, causing a heart attack.

Another common genetic defect is MTHFD. It allows homocysteine to run amok inside your cells. This can lead to cell mutations and even cancer.
What an elegant, yet destructive element homocysteine can prove to be! How can we modify homocysteine and harness its constructive power while protecting against its destructive rampage?

The answer is found in Vital Amines.

A tale of two families

Vital Amines are active enzymes in your blood, organs, and even inside your cells. You may know them by their shortened name - vitamins! In the world of "B" vitamins there are two families:

1. The MTHFR family a. B-12b. Folic acidc. B-6 d. Biotin

2. The MTHFD family a. Riboflavinb. B-1 c. Niacind. Pantothenic acid

Elevated homocysteine can be caused by genetics or poor nutrition. When a person has an active genetic defect they require intense nutrition to offset the imbalance caused by the gene mutation. Supplemental nutrition is very effective in most cases. TriVita's HCY Guard® was designed specifically for high HCY. One study on TriVita's HCY Guard found that HCY levels could be reduced by 35% in just 6 weeks!


Vital amines such as the Riboflavin family of B vitamins combine with antioxidants to help reduce the activity of cellular homocysteine. One study found that the specific antioxidant ECGC (the antioxidant found in green tea) stopped the trigger DNMT (an enzyme) from releasing homocysteine inside the cell. People consuming large amounts of ECGC have reduced DNMT and have fewer cases of cancer.

Riboflavin and ECGC are both found in Energy Now!®. In fact, just as TriVita's Sublingual B-12 and HCY Guard supplements contain the B-12 family of B vitamins, Energy Now! contains the complementary Riboflavin family of B vitamins. They work together to form a perfect B complex that helps your body reduce homocysteine.

Are you at risk?

Is there a way to tell if you have one of these common disease risks? Yes; one way is to have a genetic test performed. This is usually done by drawing enough blood to collect DNA and submitting this to one of only a few labs in North America that can perform genetic testing. A second way is to have your homocysteine levels tested. This can be performed by most medical laboratories. Ask your doctor to do this test with your annual physical.

Another indicator of elevated homocysteine is your own family tree. Does any "first-degree" relative (father, mother, brother, or sister) have any of the conditions attributed to homocysteine? If so, you likely have the gene defect. Does a "second-degree" relative (grandparents, aunts, uncles, or cousins) have any of the conditions attributed to homocysteine? If so, you may have the gene defect as well.

Did you know nutrient deficiencies can mimic a genetic defect by failing to provide the minimum amount of vital amines necessary to prevent elevated homocysteine? A poor diet, illness, pregnancy, aging, and stress can place you at risk for elevated HCY. Children and adults with asthma and irritable bowel syndrome are at high risk for elevated HCY.

Lowering your homocysteine High HCY in your blood is linked to serious illness. Helping your body reduce high HCY may greatly reduce your risk for serious illness.

These actions will also help:
  • Eat fruits and vegetables high in antioxidants - 5 servings daily for children, 7 servings for women, and 9 servings for men.

  • Reduce your stress load.
  • Get at least 30 minutes of vigorous activity every day.

  • Supplement your diet with nutrients such as TriVita's HCY Guard and Energy Now!.

  • Defeat stress by nurturing your spirit with healthy relationships and a healthy sense of purpose.

  • Remember, genes are not fate; you have as much control over your genes (through nutrients and nurturing) as they have over you.
Build a healthy foundation for your future by balancing your homocysteine.
TriVita's Weekly Wellness Report
[weeklywellnessreport@trivita.com]